The Valenzetti Equation is a fictional book by Gary Troup is a book that speaks of a mathematical equation that can predict the apocalypse, and the end of the world. One theory that I came across about the numbers that continue to show up in Lost is that they are the result of the Valenzetti Equation equalling 4 8 15 16 23 42.
The theory looks at the numbers in a different way then just a string of numbers adding up to 108 like some other theories people are using to try and figure out their meaning. This one uses the set of numbers as a date and time which if Valenzetti’s equation is correct would be the end of the world.
The date would be April 8, 2015 at 16:23:42, or 4/8/2015 at 4:23 and 42 seconds. This thoery can be backed up with a little bit of information from the show such as when the blast doors came down on Locke’s leg he saw a map, which included a phrase “low relevence to Valenzetti related research activity.
Also, the man the Hurley got the numbers from in the insitution. Some how that man knew the numbers, and possibly knew what they meant which is why he went insane. Knowing how the world was going to end could lead a man to insanity.
The numbers are obviously a sign of bad luck, as seen with all that has been happening to people around Hurley after he used them in the lottery and won. There is certainly evil about the numbers, and what could be much worse than the world coming to an end?